Insight

Now is the time to go big: Back UK Spinouts or Fall Behind

30.6.25

Image of 1400 x 500 NO TEXT Investment for Growth Science and Tech Graphics

The UK stands on the edge of a spinout revolution — but unless we act boldly, that edge could quickly become a cliff.

A lot has changed in just 12 months. New governments are settling in on both sides of the Atlantic. Policy priorities are shifting (in some cases dramatically) and the global context for science and innovation remains volatile. From geopolitical tensions to supply chain shocks and the race for tech sovereignty, the forces shaping our innovation economy are more complex than ever.

And yet, amid all this change, one thing remains constant: science doesn’t stand still. Ideas keep coming. Breakthroughs keep happening. And if we want the UK to stay ahead, the support system around those ideas must move just as fast.

Last month, I had the chance to speak about exactly this at the Creating a Scientific Superpower Conference, hosted by the Oxford-Cambridge Supercluster Board. The event brought together a world-class line-up of 31 speakers including Lord Patrick Vallance, Minister of State for Science, Research and Innovation, Shaun Grady, Chair of AstraZeneca, the Vice-Chancellors of both Oxford and Cambridge Universities alongside a host of other big names from the science and tech sectors in the UK, US and France. 

Contributors:

Because here’s the truth: the UK already has what it takes. We have the science, the talent, and a funding landscape that, despite the noise, is more resilient than it’s often given credit for. We remain a top destination for innovative companies looking to grow. But global competition is fierce, and we cannot afford to be slow. If we don’t act decisively, we risk losing out to nations investing bigger, faster, and with more strategic intent.

That urgency was echoed during the event by fellow speaker Edward Bussey, CEO of Oxford Science Enterprises, who warned:

We haven’t got 10 years to wait. There are companies right now who need that institutional money to scale and win on a global basis.

This is a pivotal moment.

We have a real opportunity to do something bold. The UK Government has made clear that science and technology are central to our national growth strategy. Recent moves from the Mansion House reforms aimed at unlocking pension fund investment, to the creation of scale-up capital pathways - show that policy is starting to align with ambition.

That alignment needs to happen quickly. Reflecting on this in his keynote speech at the same conference, Lord Patrick Vallance, Minister of State for Science, Research and Innovation, made the point plainly:  

You don’t get above average growth without innovative science and tech companies scaling and succeeding here in the UK.

But that alignment is meeting resistance. For all the promising reforms, a critical barrier remains: the UK’s tax environment is not keeping pace with the needs of scaling spinouts.

Just as companies reach the crucial point of expansion, they’re met with a fiscal landscape which too often deters rather than supports growth. Complex regulations, an uncompetitive capital gains framework, and insufficient incentives stand in contrast to the red-carpet treatment offered elsewhere.

It’s a friction point repeatedly cited by founders and investors and a key reason why some of the UK’s brightest prospects are scaling abroad rather than at home. If we want to retain and grow those companies, that needs to change, and quickly.

The case for action is clear. For every 10 high-tech jobs created in the UK, seven more are generated in local services, many of them for low-skilled workers. Innovation doesn’t just fuel scientific progress; it drives inclusive growth.

Councillor Susan Aitken, Leader of Glasgow City Council, reinforced this message during her remarks at the conference:  

Innovation can’t just drive growth - it must drive equity too. That’s what it means to build an economy that’s participative, inclusive, and resilient.

But our global peers are moving quickly. Billions are being invested elsewhere, and the world’s most promising businesses are being lured away with incentives, tax advantages, and streamlined regulatory environments. That’s why we’ve published our latest research, Now is the Time to Go Big - the second paper in our Investment for Growth series.

This report takes a hard look at the state of university spinouts in the UK, where they begin, why some succeed, and why others leave. It explores the conditions needed for these businesses to scale here, and not somewhere else.

Some key findings stand out:

70%

of UK university spinouts are still located in the cluster where they started. But nearly 1 in 3 move on, being most vulnerable when they are acquired or needing funding for growth.

6%

of companies go overseas, most often to the US - UK companies receive £1 in funding for every £8 in the US - in doing so they taking talent, value, and intellectual

3Cities

London, Cambridge, and Oxford - generate a third of all UK spinouts. Not because other places lack ideas, but because they lack the support to turn ideas into investable businesses.

To change that, we need to think beyond the “Golden Triangle.” Sharing her perspective during one of the panel sessions at Creating a Scientific Superpower, Professor Deborah Prentice, Vice-Chancellor of the University of Cambridge, highlighted the importance of a national view:  

When you hear about what Cambridge does, you're hearing about what the UK does...companies spin out from our ecosystem and scale up in Leeds, in Newcastle, not just Cambridge. That’s why we’re building infrastructure to support growth nationally, not just locally.

Spinouts outside the Golden Triangle raise less capital at every stage, with the biggest gaps in post-seed funding - precisely when companies are trying to scale. These disparities represent missed opportunities for growth across the country.

Another insight: while acquisitions often trigger a move abroad, IPOs tend to keep companies rooted. That’s a powerful signal about how to design for long-term resilience.

We also rely heavily on US venture capital, which, while valuable, introduces risk. There’s a clear need to build a stronger domestic investment base, something reforms like the Mansion House Accord and the recently published Industrial Strategy could help unlock. The £86bn committed in the Spending Review for investment in science and technology during the term of this Government, provides a meaningful start.

But without a corresponding shift in fiscal policy, the UK risks underwriting R&D only for others to capitalise on its commercial potential.

Infrastructure matters, too. World-class lab space is coming online in key clusters, but beyond those hubs we need to ensure scale-up-ready facilities are available for companies poised to grow. In addition, power and digital infrastructure are essential. The confirmation of funding for the Edinburgh supercomputer will start to redress our lagging computer power capacity, particularly when combined with efforts to address the necessary power infrastructure illustrated by announcements of mini nuclear power facilities to be provided by Rolls Royce.

But hard infrastructure is only part of the equation. A healthy housing market is just as critical. When talented people can’t find suitable, affordable homes, the innovation economy suffers. Nowhere is this more apparent than in Cambridge, where an undersupply of housing is starting to undermine the momentum of a globally significant tech ecosystem. When asked, major employers consistently cite housing as a leading constraint on growth, as the top concern for the quality of life experienced by their employees.

The opportunity in the OxCam supercluster can’t be wasted. Speaking passionately on this point, Lord Vallance said:

If we don’t make the most of the opportunity we are talking about today, we will not only be remiss but other countries will think we have gone mad. They would be falling over themselves to have the opportunity we have.

This is a challenge - and an opportunity.

Bidwells has advised clients in the science and tech sector for decades, helping to shape some of the UK’s most successful innovation clusters. We’ve seen what’s possible when great ideas meet the right environment, funding, and space to grow.

The findings of our research echo that experience. Spinouts want to stay. Groundbreaking ideas are emerging across the country. But many are being held back - by funding gaps, by lack of space, and by inconsistent support.

If we want to build a more resilient innovation economy, one which delivers jobs, skills, and long-term growth, we need to back these companies with ambition, urgency, and scale.

 

Now is the time to go big. Or risk falling behind.

Get in touch

602520

Max Bryan

Partner, Head of Laboratory & Office Agency

Max works with pioneering innovators and tech entrepreneurs, leading our unparalleled offices and labs agency team.

Read more

Related Content

Image of 1400 x 500 NO TEXT Investment for Growth Science and Tech Graphics Reports & Briefings 05.06.25

Life science spinouts are key to unlocking the UK’s global scientific potential.

Investment for Growth: Now is the time to go big

Read more
Image of WEB 2886 Investment for Growth Report Graphics Reports & Briefings 20.05.25

Is Britain Ready to Grow Again?

Investment for Growth: The case for micro-economic reforms

Read more
Image of superpower image with tint Events 05.06.25

Brought to you by the Oxford-Cambridge Supercluster & Bidwells, the Creating a Scientific Superpower conference returned for its fourth year.

Creating a Scientific Superpower 2025

Read more
Image of _G4A3762 (1) Insights 05.06.25

Speaking at the 2025 Superpower Conference, Lord Patrick Vallance delivered a powerful call to action: to unlock the full potential of the Oxford-Cambridge Supercluster and turn the UK into a true scientific superpower.

Lord Patrick Vallance: Unlocking the UK's Scientific Superpower

Read more

Contributors:

Search Bidwells